Could painkillers prevent recurring urinary system infections?

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An estimated 50% of all women will experience a urinary tract infection at some point in their lives, and 20-40% of these women will have recurring infections, putting them at risk for kidney and bloodstream infections. But now, new research suggests over-the-counter painkillers could help prevent such infections from occurring.

Detectives from Washington College Med school in St. Louis, MO, presented their findings in the annual meeting from the American Society for Microbiology.

They discovered that, by inhibiting an immune protein that triggers inflammation – known as COX-2 – they could eliminate repeat urinary system infections in rodents. They describes that COX-2 could be blocked by non-steroidal anti-inflammatory drugs (NSAIDs), including ibuprofen.

Based on the Cdc and Prevention (CDC), urinary system infections (UTIs) have the effect of around 4 million ambulatory-care visits each year in america.

Most UTIs come from the bacteria Escherichia coli, which resides in the bowel. While men will also get UTIs, women are specifically vulnerable to them as their urethra is shorter – which enables bacteria better accessibility bladder – along with a woman’s urethral opening is within closeness to bacteria sources in the anus and vagina.

ibuprofen

NSAIDs, for example ibuprofen, blocked a protein that triggers inflammation and considerably reduced vulnerability to repeat UTIs.

Every time a lady includes a Bladder infection, her likelihood of getting recurrent infections increases, and severe infections with sepsis can also be fatal.

In the past mouse studies, the scientists – brought by Thomas Hannan – discovered that the defense mechanisms overreacted to initial infections, which recommended elevated vulnerability to infections that adopted.

“We thought that the immune response was too weak in patients who kept getting urinary tract infections,” explains Hannan, “but we are learning that an overly strong immune response can be just as problematic.”

He and the team discovered that immune cells, known as neutrophils, lead to repeat infections both in ladies and rodents. The neutrophils leave tracks within the protective lining from the bladder once they burglary to battle infection, the scientists say.

Such damage could provide “footholds” that permit bacteria to seize your hands on the bladder lining and initiate severe infections.

COX-2 inhibitors reduced susceptibility to repeat infections

By manipulating the strength of the neutrophil response in mice, so it was not too little or too much, the researchers were able to wipe out UTIs without increasing the risk of future infection.

Fast facts about UTI symptoms

  • A frequent and intense urge to urinate and a painful burning during urination
  • Cloudy, dark or bloody urine, which may have a foul smell
  • Pain in the back or side below the ribs, nausea or vomiting.

They found that mice with increased susceptibility to recurring infections had more inflammatory molecules in their bladder, compared with mice that were not vulnerable to repeat infections.

However, when such mice were treated with COX-2 inhibitors, the team observed they showed a significantly reduced vulnerability to repeat infections.

After analyzing the result of COX-2 inhibitors around the immune response within the bladder, the scientists discovered that while neutrophils still joined the bladder in large figures, they caused considerably less harm to the protective lining.

As a result, they thinks COX-2 inhibitors can selectively goal for that negative effects of inflammation and keep the advantageous reactions.

Senior author Scott Hultgren, director from the Center for Women’s Infectious Disease Research at Washington College, states their answers are “encouraging,” and they “aspire to verify the possibility advantages of COX-2 inhibitors soon inside a large medical trial.Inch

Hannan further comments:


”If we can confirm this link in clinical trials, many people potentially could benefit very quickly. But for now, it’s important to remember that urinary tract infections are serious, and antibiotic treatment is often necessary. Patients should not treat these infections on their own without help from a medical provider.”

In 2013, Medical News Today reported on a study that suggested cranberry powder can inhibit the bacterium Proteus mirabilis, a bug commonly found in complicated UTIs.

 

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