Great news: frozen fecal transplantation competitive with fresh

Clostridium difficile infection presents a significant healthcare burden treatments are restricted, which is connected with clinical and infection control issues. Recently, utilization of fecal microbiota transplantation has been shown to create high cure rates, but you will find logistical difficulties that include using fresh material. Now, new research shows that using frozen stool material is equally as effective as while using fresh version.

Frozen samples
Transplantation with frozen fecal samples is just as effective as using fresh samples in fighting CDI, a new study suggests.

The research – brought by Dr. Christine H. Lee, of McMaster College in Ontario, Canada – is printed in JAMA.

Recurrence of Clostridium difficile infection (CDI) is of particular concern inside a healthcare setting.

Based on the study authors, previous research has shown that 10-50% of recurring CDI cases are closely related to reinfections, instead of recurrence from the initial infection, which indicates that irritated microbiota plays a part in reinfection.

In addition, greater than 60% of patients with CDI experience subsequent infections.

Authorities in the Cdc and Prevention (CDC) observe that C. difficile was believed to result in nearly 500, 000 infections in america this year, and 29,000 died within thirty days to be initially identified.

‘No differences in adverse or serious events between treatment groups’

Although treatment options for recurrent CDI are limited, restoring “good” bacteria in the gut through fecal microbiota transplantation (FMT) has proven itself as an effective treatment.

Fast facts about CDI

  • Health care workers can spread the bacteria to patients through hand contact
  • Symptoms include watery diarrhea, fever, loss of appetite, nausea and abdominal pain
  • People who require prolonged use of antibiotics and the elderly are at greater risk.

Find out more about C. difficile

Using frozen-and-thawed FMT offers several positive aspects, including lower costs (because of a decrease in number and frequency of donor screenings), immediate availability and simpler delivery and storage options.

So far, however, previous studies haven’t directly in comparison the potency of frozen FMT with fresh FMT.

As a result, the scientists at random designated 232 grown ups with recurrent or refractory CDI to get either frozen or fresh FMT with an enema. As a whole, 114 patients received frozen FMT and 118 received fresh between This summer 2012-September 2014.


Results showed that the proportion of patients whose diarrhea was resolved without relapse at 13 weeks was 83.5% for those in the frozen FMT group, compared with 85% for the fresh FMT group.

The researchers conclude that there are no differences in adverse or serious events between treatment groups.

“Given the potential advantages of providing frozen FMT, its use is a reasonable option in this setting,” they write.

‘Best evidence to date supporting use of frozen stool’

Regardless of the large sample size, the scientists admit some restrictions for their study. First of all, their 13-week follow-up period isn’t lengthy enough to evaluate lengthy-term safety from the treatment.

Furthermore, there is a minimal quantity of stool contributors, that they say could be described as a limitation.

They observe that the lengthy-term safety of FMT must be fully investigated through extended follow-up of the sufferers, and therefore, they’re presently performing a ten-year follow-up analysis to completely flesh the lengthy-term negative or positive outcomes.

Within an associated editorial, Drs. Pretti Malani and Krishna Rao, from the College of Michigan-Ann Arbor, write the study’s results present the “best evidence up to now supporting using frozen stool,” adding that it’ll “likely expand the supply of FMT for patients with recurrent CDI.”

They add:


”The ability to use frozen stool eliminates many of the logistical burdens inherent to FMT, because stool collection and processing need not be tied to the procedure date and time.

This study also provides greater support for the practice of using centralized stool banks, which could further remove barriers to FMT by making available to clinicians safe, screened stool that can be shipped and stored frozen and thawed for use as needed.”

They add that procedure costs could also decrease, given that donor screening is expensive.

Medical News Today recently reported on a study that suggested exercise in early life affects the gut flora, promoting better health later on.

 

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