What’s the over-the-counter genetic test – the insight saliva collection package?


MNT Knowledge Center

The Insight Saliva Collection KitTM is a personal genetic testing kit which can give customers information about their genetics – which diseases they are at a higher risk of developing, which medications they would respond to best, and the likelihood of passing on susceptibility to certain diseases to their children.

The genetic test kit consists of:

  • A small saliva collection kit
  • A set of instructions, which according to the manufacturers, Pathway Genomics, are simple to understand and follow.
  • A pre-postage paid envelope

How it works

  • Getting the saliva kit

    At the moment (May 2010) customers can order it online or buy it at over 6,000 Walgreens pharmacy outlets in the USA.

  • Collect and activate

    The customers follow the “easy step-by-step” instructions to:

    • Accurately collect a small sample of saliva in the tube provided
    • Activate their private, password-protected account online


  • Send the sample

    Using a pre-paid Fed-Ex package envelope (included), customers send their sample to Pathway’s secure, onsite CLIA-certified lab. The company says personal information is protected for privacy purposes.

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Checking the test results

Customers go to the Pathway website, and into a secure web page which they access with their password. The following results can be accessed:

  • An individualized Genetic Insight™ Report for Drug Response ($79)
  • Pre-Pregnancy Planning ($179)
  • Health Conditions ($179)
  • A combination of all three ($249)

Identifying genetic risk for health conditions

The customer’s DNA is scanned for genetic markers that indicate risk for health conditions. Some markers have been researched more thoroughly than others.

The customer has the option of having their saliva sample stored in a secure DNA LockboxTM to be retested as new scientific breakthroughs emerge.

Below is an example of conditions/diseases the genetic test can report on (whether the customer has genetic markers that raise the risk of developing these diseases/conditions):

  • Age-related macular degeneration
  • Alzheimer’s disease, late onset
  • Amyotrophic lateral sclerosis (sporadic)
  • Asthma
  • Atrial fibrillation
  • Breast cancer (females only)
  • Colorectal cancer
  • Coronary artery disease
  • Diabetes, Type 1
  • Diabetes, Type 2
  • Glaucoma
  • Hypertension
  • Leukemia, chronic lymphocytic
  • Lung cancer
  • Melanoma
  • Multiple sclerosis
  • Myocardial infarction
  • Obesity
  • Osteoarthritis
  • Parkinson’s disease
  • Peripheral arterial disease
  • Prostate cancer (males only)
  • Psoriasis
  • Rheumatoid arthritis
  • Systemic lupus erythematosus
  • Ulcerative colitis

Drug responses and adverse reactions (possible undesirable side effects)

The exam can identify potential reactions to a particular medications and also to which of them the client might have adverse responses. This may help a physician get the best medication for any patient – the one which might have the very best result, and which of them to prevent. Based on Path Genome, roughly 106,000 people die and a pair of.two million experience serious adverse occasions by drug responses within the U . s . States yearly.

Examples of possible drug responses tested are:

  • Abacavir Hypersensitivity
  • Caffeine Metabolism
  • Carbamazepine Hypersensitivity
  • Clopidrogel Metabolism
  • Methotrexate Toxicity
  • Statin Induced Myopathy
  • Statin protection against myocardial infarction
  • Tamoxifen Response
  • Warfarin Metabolism

Source: Pathway Genomics

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