Could low vitamin D increase the chance of leukemia?
Most cases of leukemia around the world may result from vitamin D deficiency because of low sunlight exposure. This is actually the conclusion of new research printed in PLOS One.
Scientists suggest low vitamin D levels, mediated by low UVB exposure, may result in many leukemia cases worldwide.
Leukemia is really a cancer from the bloodstream cells, most generally affecting the white-colored bloodstream cells, or leukocytes, which help fight infection.
There have been around 352,000 new installments of leukemia identified worldwide this year, and this past year, greater than 54,000 installments of cancer were identified in america alone.
While researchers continue to be unclear about the precise reasons for leukemia, genetic and ecological factors are believed to may play a role.
Numerous research has proven that vitamin D metabolites within the bloodstream Known as 25-hydroxyvitamin D, or 25(OH)D, that is an indication from the body’s vitamin D levels – communicate with acute myeloid leukemia (AML) cells. Furthermore, some research has recognized low vitamin D levels in patients with AML.
While vitamin D can be found in some meals, including oily fish, cheese and egg yolks, it’s contained in a small amount. Your body’s best supply of vitamin D is sunlight ultraviolet B (UVB) radiation in the sun penetrates bare skin, inducing vitamin D synthesis.
Within this latest study, coauthor Cedric Garland, adjunct professor within the Department of Family Medicine and Public Health in the College of California-North Park, and co-workers attempted to investigate whether low UVB exposure and occasional vitamin D levels are connected with leukemia risk.
Leukemia rates highest in countries farther from the equator
Garland and colleagues analyzed data from the International Agency for Cancer Research’s (IARC) Global Cancer (GLOBOCAN) 2012 database.
Fast facts about leukemia
- Leukemia accounted for around 3.3% of all new cancer cases in the US last year
- Around 1.5% of men and women in the US will be diagnosed with leukemia at some point in their lives
- Around 58.5% of people with leukemia survive 5 years or more after diagnosis.
Learn more about leukemia
The team looked at the age-adjusted leukemia incidence rates for 172 countries, and the cloud cover-adjusted UVB irradiance for each country was assessed using data from the International Satellite Cloud Climatology Project.
The researchers found that individuals living in countries farther away from the equator, such as the US, Australia, New Zealand, Canada and Ireland, were at least twice as likely to have leukemia as people living in countries closes to the equator, such as Nigeria, Bolivia, Samoa and Madagascar.
The association continued to be after comprising sex-specific existence expectancy and altitude, based on the authors.
They describes that people who live far away from the equator are uncovered to solar power which has traveled farther with the Earth’s atmosphere, which reduces the quantity of UVB radiation that will reach your skin.
As a result, the scientists express it is “plausible” much from the leukemia burden around the world is because of low vitamin D levels brought on by low UVB exposure.
“Skin photosynthesis makes up about the great majority of 25(OH)D concentration. Consequently, the inverse association between cloud-modified solar UVB exposure and incidence rates will probably be mediated by circulating 25(OH)D, that is highly determined by solar UVB irradiance,” they explain, adding:
“Importantly, these results suggest that increased levels of UVB irradiance and vitamin D may help prevent development of leukemia.”
As the team states some key talents of the study would be the inclusion of 1000’s of leukemia cases from 100s of nations and also the fact the findings are in line with is a result of previous studies, they admit there are several restrictions.
For instance, these were not able to manage for additional factors that could fuel variations in leukemia risk between nations. “A few of these confounders could be very influential on risk for leukemia,” they note.
Still, Garland and co-workers believe the association between low UVB exposure, low vitamin D levels and leukemia warrants further analysis.
While vitamin D deficiency continues to be associated with numerous health issues, research conducted recently as stated by Medical News Today indicates greater monthly doses from the vitamin could raise the chance of falls among seniors.